About EDS-Kcr

With the rapid advancement of proteomics, post-translational modifications (PTMs) of proteins, particularly lysine crotonylation (Kcr), have become increasingly important in basic research, drug development, and disease treatment. Given the limitations of current technologies for identifying these modifications, such as complex procedures, high costs, and time consumption, we have developed a novel bioinformatics tool named EDS-Kcr. This tool integrates the state-of-the-art protein language model ESM2 with deep supervision techniques to enhance the efficiency and accuracy of Kcr site prediction. The development of the EDS-Kcr model not only overcomes many of the limitations of current technologies but also provides an efficient and reliable tool applicable to disease diagnosis and drug development, marking a significant advancement in the fields of protein engineering and bioinformatics.